0102030405
High brain-penetrant microtubule stabilizers (MSA)
2024-07-19
- Program：High brain-penetrant microtubule stabilizers (MSA)
- Indication: Brain tumor, brain metastasis
- Status：PCC
- Collaboration Opportunity: Equity financing, cooperative development, product transfer, etc.
- Highlights：
- High brain penetration: Demonstrates potent cytotoxicity across multiple cancer cell lines, addressing unmet medical needs;
- High water solubility: Has excellent oral bioavailability.
- Non-resistant: Not a Pgp substrate, unlikely to develop resistance.
- Low hERG activity: A novel allosteric SHP2 inhibitor targeting RTK activation and KRAS/BRAF mutant cancers, without CYP inhibition, showing promising efficacy in mouse PDX GBM models.
- Small molecule with low "production and sales costs."